- June 18
- The Oakland Athletics beat the Kansas City Royals 21-3; the 18-run difference is largest margin of victory for the Athletics and the largest margin of defeat for the Royals in the teams' respective histories. [56]
- June 19
- The Los Angeles Lakers defeat the Indiana Pacers 116-111 in Game 6 of the 2000 NBA Finals, winning the series. [21]
- July 2
- France beats Italy 2-1 to win Euro 2000 with a golden goal. [21]
- July 6
- The American Sportscasters Association vote Vin Scully the Number 1 sportscaster of the 20th century. [56]
- July 16
- An 1919 Chicago 'Black Sox' autographed baseball is auctioned for US$93,666 on eBay. The ball's autographs include "Shoeless" Joe Jackson. [56]
- July 23
- Cincinnati Reds' shortstop Barry Larkin agrees to a three-year, US$27 million contract extension. [56]
- September 15
- (to October 1) The Games of the XXVII Olympiad are held in Sydney, Australia. [7] [21]
- September 27
- The United States Olympic team beats the favored Cuban team to win the country's first gold medal in baseball. [56]
- October 1
- Closing ceremony of Games of the XXVII Olympiad in Sydney, Australia. [21]
- October 8
- At Shea Stadium, the New York Mets defeat the San Francisco Giants to win the National League Division Series in four games. [56]
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- October 17
- The New York Yankees defeat the Seattle Mariners to win their 37th American League pennant. [56]
- October 20
- Toronto Blue Jays signs Carlos Delgado to a Major League record four-year $68 million contract. [56]
- October 26
- The New York Yankees defeat the New York Mets in Game 5 of the 2000 World Series, 4-1, to win their 26th World Series title. This was the first matchup between the two crosstown rivals. [21] [56]
- November 17
- Pittsburgh Pirates' catcher Jason Kendall signs a US$60 million, six-year contract extension. [56]
- November 26
- The BC Lions win the Canadian Football League Championship for the first time since 1994, defeating the Montreal Alouettes 28-26 in the 88th Grey Cup at McMahon Stadium in Calgary, Alberta. [21]
- November 30
- Mike Mussina signs a US$88.5 million, six-year contract with the New York Yankees. [56]
- December 9
- The Colorado Rockies announce the signing of pitcher Mike Hampton to a eight-year, US$123.8 amillion contract. [56]
- December 11
- Alex Rodriguez signs the richest contract in sports history, a ten-year deal with the Texas Rangers worth US$252 million. [56]
- December 13
- The Boston Red Sox sign Manny Ramirez to an eight-year, $160 million contract. [56]
2001
- January 9
- The Cleveland Indians sign Juan Gonzalez to a one-year, US$10 million deal. [56]
- January
- Nevada gaming board withdraws state ban on wagering on college sports teams based in Nevada. [818.xix]
- January 27
- A plane crashes 40 miles east of Denver, Colorado, killing two players of the Oklahoma State University basketball team, six team staffers, and the two-person crew. [22]
- January 28
- Super Bowl XXXV: The Baltimore Ravens beat the New York Giants 34-7. [22]
- February 9
- Derek Jeter and the New York Yankees finalize a $189 million, 10-year contract, making Jeter the second highest paid player in the history of the sport. [56]
- February 11
- The East beats the West 111-110 in the 50th NBA All Star Game in Washington, DC. [22]
- Three Rivers Stadium, 30-year-old home of the Pittsburgh Pirates, is imploded. [22] [56]
- March 3
- Rusty Greer signs a $21.8 million, three-year contract extension with the Texas Rangers. Greer could make as much $36 million with incentives and options. [56]
- March 24
- During an exhibition baseball game between the San Francisco Giants and the Arizona Diamondbacks, Randy Johnson's fastball hits and instantly kills a dove flying in front of home plate. The bird appears to explode as the pitch sends it over the catcher's head. [56]
- March 29
- Todd Helton signs a nine-year, $141.5 million contract extension with the Colorado Rockies. [56]
- April 1
- The first Major League Baseball game is played in Puerto Rico, as the Toronto Blue Jays defeat the Texas Rangers 8-1. [56]
- April 9
- The Cincinnati Reds defeat the Pittsburgh Pirates 8-2 in the first game at PNC Park, the first two-deck stadium built in the U.S. since Milwaukee County Stadium opened in 1953. [22]
- April 25
- San Diego Padres' outfielder Rickey Henderson breaks the career walks record established by Babe Ruth when he receives his 2,063rd base on balls. [56]
- May 10
- A soccer game stampede in Ghana kills over 120. [22]
- May 23
- Bayern München wins the UEFA Champions League. [22]
- June 5
- With a home run in his 57th game, Barry Bonds becomes the fastest player ever to hit 30 home runs. [56]
- June 9
- The Colorado Avalanche win their second Stanley Cup Championship with a 3-1 victory in Game 7 of the 2001 Stanley Cup Finals over the defending champion New Jersey Devils at Pepsi Center in Denver, Colorado. [22]
- June 15
- The Los Angeles Lakers beat the Philadelphia 76ers 4-1 to win their second straight NBA Title. They also finish with the best overall record in playoff history, 15-1. [22]
- June 17
- A.S.Roma wins the scudetto (Italian championship). [22]
- June 20
- With his 38th homerun of the season, Barry Bonds breaks the major league record for home runs hit before the All-Star game. [56]
- July 13
- Beijing wins the bid to host the 2008 Summer Olympics. [22]
- August 5
- The Cleveland Indians defeat the Seattle Mariners 15-14 in a record-setting baseball game known as the Impossible Return. [22]
- August 7
- Black Betsy, Shoeless Joe Jackson's 40-ounce warped hickory bat, is won in a 10-day eBay auction. The $577,610 price tag is believed to be the largest amount ever paid for a baseball bat. [56]
- September 6
- Barry Bonds becomes the fifth major leaguer to hit 60 home runs in a season, reaching the milestone in the shortest time, just 141 games. [56]
- September 13
- Due the terrorist attacks on the World Trade Center and the Pentagon, Major League Baseball postpones all games through September 17. [56]
- September 21
- Sports return to New York for the first time since the terrorist attacks with the New York Mets/Atlanta Braves game at Shea Stadium. Mike Piazza hits a two-run home run in the 8th inning off Steve Karsay to win the game 3-2. [22]
- October 4
- Rickey Henderson of the San Diego Padres breaks Ty Cobb's record to become the leading run-scorer in baseball history, with 2,246th runs. [56]
- October 5
- The Atlanta Braves defeat the Florida Marlins 20-3 to clinch the National League East title and becomes the first team in professional sports to win 10 consecutive division titles. [56]
- Barry Bonds of the San Francisco Giants breaks the single season home run record with his 71st and 72nd home runs of the year. Both are off pitcher Chan Ho Park of the Los Angeles Dodgers. [22] [56]
- The Seattle Mariners break the Major League Baseball record for wins in a season set by the 1998 New York Yankees, winning their 115th game, defeating the Texas Rangers at Safeco Field. The Mariners finish the season 116-46. [22]
- October 6
- The Seattle Mariners tie the 1906 Chicago Cubs with 116 wins in a single season for winningest team in major league history. [56]
- October 14
- Michael Schumacher wins the 52nd FIA Formula One World Championship, with a record margin of 58 points. [22]
- October 15
- The Arizona Diamondbacks win the National League Division Series beating the Saint Louis Cardinals. [56]
- The New York Yankees beat the Oakland Athletics to win the American League Division Series. [56]
- November 1
- Derek Jeter hits the Major League Baseball's first November home run at the World Series. [22]
- November 4
- The Arizona Diamondbacks beat the three-time defending World Series Champions New York Yankees in seven games to win their first ever baseball World Series Championship. [22] [56]
- November 11
- St. Louis Cardinals' first baseman Mark McGwire turns down a two-year, US$30 million extension, retiring from the sport. [56]
- November 25
- The Calgary Stampeders win the Canadian Football League Championship for the first time since 1998, defeating the Winnipeg Blue Bombers 27-19 in the 89th Grey Cup at Olympic Stadium in Montreal, Quebec. [22]
- December 13
- The New York Yankees sign Jason Giambi to a seven-year deal worth US$120 million. [56]
- December 22
- Chan Ho Park signs a five-year, $65 million deal with the Texas Rangers. [56]
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