Reversing AIDS and Preventing Recurrence

The Dr. Harold D. Foster Theory

In 1997, Dr. Ethan Will Taylor and his colleagues in the Departments of Medical Chemistry and Computer Science at the University of Georgia, Athens, Georgia, discovered HIV-1 had a gene identical to the human gene coded for the for the production of the enzyme glutathione peroxidase.1,2 To prove the identified HIV-1 gene enabled viral production of this selenoenzyne, Taylor and colleagues3 cloned the gene and inserted it into animal cells. As a consequence, the modified animal cells greatly increased their production of glutathione peroxidase. This result proved beyond any reasonable doubt that HIV-1 competes with seropositive individuals for the nutrients necessary for the production of glutathione peroxidase.

Concurrently, Dr. K.D. Aumann and co-workers of the Department of Biological Chemistry at the University of Padova, Italy4-6 began a detailed study of the nature of the glutathione peroxidases, determining that they "are characterized by a catalytically active selenium which forms the center of a strictly conserved triad composed of selenocysteine, glutamine, and tryptophan". In short, the enzyme HIV-1 is encoding for consists of a combination of one trace element (selenium) and three amino acids (cysteine, glutamine and tryptophan).

In 2000, Dr. Harry D. Foster,7-10 of the Department of Geography, University of Victoria, brought forth the theory that as HIV-1 replicates it must remove selenium, cysteine, glutamine and tryptophan from seropositive individuals. An enormous body of literature shows AIDS patients are very deficient in these four nutrients and supports Foster’s theory.11-33 Beyond this, the symptoms caused by the individual deficiencies of these nutrients are well known. Selenium inadequacy, for example, promotes Keshan disease (a cardiomyopathy). Tryptophan deficiency leads to dementia. Foster argues AIDS magnifies the impact of the overlapping of these four sets of deficiencies, caused because HIV-1 encodes the glutathione peroxidase and so robs its victims of selenium, cysteine, glutamine and tryptophan (Table 1).

 

Table 1: AIDS: The Viral Induced Nutrient Deficiency Disease

AIDS

Nutrient or Enzyme

(# Reference Source)

Deficiency Symptoms (Examples)

Glutathione (42)

Increased free radical damage, higher incidence of cancer, heart disease, premature aging.

Glutathione peroxidase (43)

Elevated hydrogen peroxide, oxidative stress and lipid peroxidation.

Selenium (39, 41)

Depressed glutathione peroxidase. Oxidative stress. Depressed CD4 T lymphocytes, depressed triiodothyronine (hypothyroidism). Cancers of lung, colon, etc. Myocardial infarction, Kaposi’s sarcoma (with HHV-8), depression.

Cysteine (44)

Depressed glutathione and sulphur. Poor wound and skin healing. Psoriasis. Abnormal immune function, secondary infections and cancers.

Glutamine (29, 30, 44)

Depression. Abnormal intestine permeability, diarrhea, muscle wasting.

Tryptophan (44)

Depressed niacin and serotonin levels. Immune incompetence. Neuroendocrine disregulation, polyneuropathy, dementia, dermatitis, diarrhea.

If Foster’s theory, as supported by the literature, holds true, then this is a case where replenishing selenium, cysteine, glutamine and tryptophan should reverse AIDS, and possibly prevent its recurrence.

Foster’s theory provides the potential of a readily accessible and affordable therapy for AIDS patients in both developed and developing nations.

Testimonials

The testimony of informal individual use of this nutritional protocol in Victoria, Canada and in a physician-directed trial currently underway in Botswana strongly suggests that it does. Below are comments from individuals involved:

    1. "Dear Dr. Foster,
    2. I am writing to thank you for your advice about selenium and other nutrients to take for HIV and Hep C. As you know my partner has HIV, and Hep C. He has also been sick with Hep A and B due to his past lifestyle as an IV drug user. The road to recovery has been a long and exhausting one, but I credit the information you shared with us as part of what has helped him to lead a healthy life now. He is back to work by the way, and his viral load is undetectable. He looks healthy again.

      My partner began taking the cocktail while still using cocaine, heroin and other drugs, as well as drinking his face off. The alcoholism at first got worse as he sought to replace harder drugs with beer. During this time he had full blown AIDS and it seemed certain he would be dead soon despite the cocktail prescription.

      After talking to you and reading your book together, we focused on nutrition, specifically getting the Selenium into him, and also me as an extra protection against exposure to the viruses. We also understood better the relationship between the drugs and alcohol and the progression of his diseases. Even after the HIV seemed to be under control, his Hep C was really bothering him. As he learned to take better care of himself nutritionally, and eventually managed to quit all substances with the help of NA, he seemed to be on the road to health. Within a few months his viral load was again undetectable.

      When he went travelling and was unable to access either the cocktail or the nutrients he quickly became ill again. By the time he came home he was once again quite sick, full blown AIDS. However after returning home and once again taking selenium and the other nutrients you suggested, as well as returning to the cocktail, he quickly got better. This time the improvement happened over a period of weeks.

      He once again mentioned that he believed one of the nutrients he was taking because of your book also helped him in the fight against his cravings. I don’t know if this was his imagination or real, but it might be worth looking into.

      Once again thanks for your help."

    3. Excerpts from an email sent to Dr. Foster, by a Canadian vitamin/mineral company that set up a trial of nutrient treatment for AIDS, based on Dr. Foster's theory, in Botswana, reads:
    4. "I picked two candidates personally who have fully blown AIDS with relevant symptoms like diarrhoea, skin rash, loss of weight and a lack of appetite. One of these candidates has a severe complication of syphilis which has slowed his recovery somewhat, but still within two weeks of trials his skin rash, diarrhoea, and fatigue have all but disappeared. The lady candidate gained 3 kg in two weeks and now "eats like a horse". She resumed work last Tuesday after several weeks of absence. I am gaining confidence in this treatment by the day and I hope the same would apply to the remainder of the trial candidates".

      and,

      "A lady that started the regimen three weeks back has just tested NEGATIVE for HIV and her CD4 count has shot up from 500 to 700!"

    5. Excerpts from a later email sent to Dr. Foster from the same Canadian vitamin/mineral company freely distributing select nutrients, following Dr. Foster's theory, to doctors in Botswana directed to give them to patients with AIDS and to record their progress, reads:

"we are in constant touch with the relevant doctors regarding patients progress and we get verbal confirmation of 99% rate".

Further Clinical Trials

At this time, a larger formal clinical trial of Foster’s theory is being arranged. The trial will involve simple, inexpensive, easy-to-administer, common pharmaceutical products.

Based on Foster’s theory, one could expect to reverse all the obvious symptoms of an AIDS patient in one month or less, at a cost of $100 or less, per patient.

Updates on this trial will be posted as soon as they are available.

For more information

For information on products developed by Dr. Foster, please contact: info@fosterlabs.com

For a free, complete, downloadable pdf copy of Dr. Foster's book, What really causes AIDS, published by Trafford Publishing, please visit
http://www.hdfoster.com/WhatReallyCausesAIDS.pdf

To view the pdf file of Dr. Foster's book, you will need Adobe Acrobat Reader installed on your computer. Get Adobe Acrobat Reader here.

If you would like more information about Dr. Foster's research, please visit http://www.hdfoster.com/.

References

  1. Taylor E.W., Nadimpalli R.G., Ramanathan C.S. Genomic structures of viral agents in relation to the biosynthesis of selenoproteins. Biol Trace Elem Res 1997; 56(1): 63-91.
  2. Taylor E.W., Bhat A., Nadimpalli R.G., Zhang W., Kececioglu J. HIV-1 encodes a sequence overlapping env. gp41 with highly significant similarity to selenium dependent glutathione peroxidases. Journal of AIDS and Human Retrovirology 1997; 15(5): 393-394.
  3. Zhao L., Cox A.G., Ruzicka J.A., Bhat A.A., Zhang W., Taylor E.W. Molecular modeling and in vitro activity of an HIV-1-encoded glutathione peroxidase. Proc Natl Acad Sci USA, 2000 June 6; 97(12): 6356-6361.
  4. Maiorino M., Aumann K.D., Brigelius-Flohe R., Doria D., van den Heuvel J., McCarthy J., Roveri A., Ursini F., Flohe L. Probing the presumed catalytic triad of a selenium-containing peroxidase by mutational analysis. Z Ernahrungswiss 1998: 37 Suppl 1: 118-131.
  5. Aumann K.D., Bedorf N., Brigelius-Flohe R., Schomburg D., Flohe L. Glutathione peroxidase revisited - simulation of the catalytic cycle by computer-assisted molecular modelling. Biomed Environ Sci 1997; 10(2-3): 136-155.
  6. Maiorino M., Aumann K.D., Brigelius-Flohe R., Doria D., ven den Heuvel J., McCarthy J., Roveri A., Ursini F., Flohe L. Probing the presumed catalytic triad of selenium-containing peroxidases by mutational analysis of phospholipid hydroperoxidase glutathione eroxidase (PHGPx). Biol Chem Hoppe Seyler 1995; 376(11): 651-650.
  7. Foster H.D. AIDS and the "Selenium - CDR cell tailspin": The geography of a pandemic. Townsend Letter for Doctors and Patients, 2000; 209: 94-99.
  8. Foster H.D. Why HIV-1 has diffused so much more rapidly in Sub-Saharan Africa than in North America. Medical Hypotheses, 2003; 60(4): 611-614.
  9. Foster H.D. How HIV-1 kills: implications for the treatment and prevention of AIDS. Townsend Letter for Doctors and Patients 2002; 255: 76-78.
  10. Foster H.D. What really causes AIDS, 2002; Victoria; Trafford Publishing.
  11. Baum M.K. Role of micronutrients in HIV-infected intravenous drug users. JAcquir Immune Defic Synd 2000; 25(Suppl 1): S49-52.
  12. Campa A., Shor-Posner G., Indacochea F., Zhang G., Lai H., Asthana D., Scott G.B., Baum M.K. Mortality risk in selenium-deficient HIV-positive children. J Acquir Immun Defic Syndr Hum Retrovirol 1999; 20(5): 508-513.
  13. Baum M.K., Shor-Posner G. Micronutrient status in relationship to mortality in HIV-1 disease. Nutr Rev 1998; 56(1 Pt. 2) S135-139.
  14. De Roasa S.C., Zaretsky M.D., Dubs J.G., Roederer M., Anderson M., Green A., Mitra D., Watanabe N., Nakamura H., Tijoe I., Deresinski S.C., Moore W.A., Ela S.W., Parks D., Herzenberg L.A. N-acetylcysteine replenishes glutathine in HIV infection. Eur J Clin Invest 2000; 30(10): 915-929.
  15. Raju P.A., Herzenberg L.A., Roederer M. Glutathione precursor and antioxidant activities of N-acetylcysteine and oxothiazolidine carboxylate compared in in vitro studies of HIV replication. AIDS Res Hum Retroviruese 1994; 10(8): 961-967.
  16. Breitkreutz R., Pittach N., Nebe C.T., Schuster D., Brust J., Beichert M., Hack V., Daniel V., Edler L., Droge W. Improvement of immun function in HIV infection by sulfur supplementation: two randomized trials. J Mol Med 2000; 78(1): 55-62.
  17. Look M.P., Rockstroh J.K., Rao G.S., Barton S., Lemoch H., Kaiser R., Kupfo B., Sudhop T., Spengler U., Sauerbruch T. Sodium selenite and N-acetylcysteine in antiretroviral-niave HIV-1-infected patients: a randomized, controlled pilot study. Eur J Clin Invest 1998; 28(5): 389-397.
  18. Shabert J.K., Winslow C., Lacy J.M., Wilmore D.W. Glutamine-antioxidant supplementation increases body cell mass in AIDS patients with weight loss: a randomized double-blind controlled trial. Nutrition 1999; 15(11/12): 860-864.
  19. Noyer C.M., Simon D., Borczuk A., Brandt L.J., Lee M.J., Nehra V. A double-blind placebo-controlled pilot study of glutamine therapy for abnormal intestinal permeability in patients with AIDS. Am J Gastroenterol 1998; 93(6): 972-975.
  20. Kohler H., Ruggeberg J., Langer K., Jablonowski H., Adam R., Wahn V., Schroten H. Glycyl-glutamine improves in vitro lymphocyte proliferation in AIDS patients. Evr J Med Res 2000; 5(6): 263-267.
  21. Clark R.H., Feleke G., Din M., Yasmin T., Singh G., Khan F.A., Rathmacher J.A. Nutritional treatment for acquired immunodeficiency virus-associated wasting using beta-hydroxy beta-methylbutyrate, glutamine and arginine; randomized, double-blind, placebo-controlled study. J Parenter Enteral Nutr 2000; 24(3): 133-139.
  22. Murray M.F. Niacin as a potential AIDS prevention factor, Med Hypotheses 1999; 53(5): 375-379.
  23. Fuchs D., Gisslen M., Larsson M., Norktans G., Hagberg L., Wachter H. Increase of tryptophan in serum and in cerebrospinal fluid of patients with HIV infection during zidovudine therapy. Adv Exp Med Biol 1996; 398: 131-134.
  24. Brown R.R., Ozaki Y., Datta S.P., Borden E.C., Sondel P.M., Malone D.G. Implications of interferon-induced tryptophan catabolism in cancer, auto-immune diseases and AIDS. Adv Exp Med Biol 1991; 294: 425-435.
  25. Fuchs D., Forsman A., Hagberg L., Larsson M., Norkrans G., Reibnegger G., Werner E.R., Wachter H. Immune activation and decreased tryptophan in patients with HIV-infection. J Interferon Res 1990; 10(6): 599-603.
  26. Werner E.R., Fuchs D., Hausen A., Jaeger H., Reibnegger G., Werner-Felmayer G., Dierich M.P., Wachter H. Tryptophan degradation in patients infected by human immunodeficiency virus. Biol Chem Hoppe Seyler 1988; 369(5): 337-340.
  27. Gladyshev V.N., Stadtman T.C., Hatfield D.L., Jeang K.T. Levels of major selenoproteins in T cells decrease during HIV infection and low molecular mass selenium compounds increase. Proc Natl Acad Sci USA 1999; 96(3): 835-839.
  28. Hori K., Hatfield D., Maldarelli F., Lee B.J., Clouse K.A. Selenium supplementation suppresses tumor necrosis factor alpha-induced human immunodeficiency virus type 1 replication in vitro. AIDS Res Retroviruses 1997; 13(15), 1325-1332.
  29. Droge W., Breitkreutz R. Glutathione and immune function. Proc Nutr Soc 2000; 59(4): 595-600.
  30. Droge W., Holm E. Role of cysteine and glutathione in HIV infection and other diseases associated with muscle wasting and immunological dysfunction. FASEB J 1997; 11(13): 1077-1089.
  31. Breitkreutz R., Pittack N., Nebe C.T., Schuster D., Brust J., Beichert M., Hack V., Daniel V., Elder L., Droge W. Improvement of immune function in HIV infection by sulfur supplementation: two random trials. J Mol Med 2000; 78(1): 55-62.
  32. Droge W. Cysteine and glutathione in catabolic conditions and immunological dysfunction. Curr Opin Clin Nutr Metab Care 1999; 2(3): 227-233.
  33. Roths S., Droge W. Glutathine reverses the inhibition of T cell responses by superoptimal numbers of "nonprofessional" antigen presenting cells. Cell Immunol 1994; 155(1): 183-194.

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